Human neuromelanin an endogenous microglial activator for dopaminergic neuron death
نویسندگان
چکیده
منابع مشابه
Human neuromelanin: an endogenous microglial activator for dopaminergic neuron death.
Substantial evidence indicates that neuroinflammation caused by microglial activation in substantia nigra is critical in the pathogenesis of dopaminergic neurodegeneration in Parkinson's disease (PD). Increasing data demonstrates that environmental factors such as rotenone, paraquat play pivotal roles in dopaminergic neuron death. Here, potential role and mechanism of neuromelanin (NM), a major...
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Inflammation plays an important role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease. Recent reports have indicated that andrographolide (ANDRO) has an anti-inflammatory effect by modulating macrophage and neutrophil activity. Whereas microglia, the counterpart of macrophages in the brain, are pivotal in the inflammatory process in the central nervous sy...
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PURPOSE The dopamine hypothesis suggests that excessive dopamine release results in the symptoms of schizophrenia. The purpose of this study was to elucidate the dopaminergic and noradrenergic neurons using 3-T neuromelanin magnetic resonance imaging (MRI) in patients with schizophrenia and healthy control subjects. METHODS We prospectively examined 52 patients with schizophrenia (M: F = 27∶2...
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ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 2013
ISSN: 1945-0494,1945-0508
DOI: 10.2741/e591